Sung, H. et al. International Most cancers Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 International locations. CA Most cancers J. Clin. 71, 209–249 (2021).
Smyth, E. C., Nilsson, M., Grabsch, H. I., van Grieken, N. C. & Lordick, F. Gastric most cancers. Lancet. 396, 635–648 (2020).
Berlth, F., Bollschweiler, E., Drebber, U., Hoelscher, A. H. & Moenig, S. Pathohistological classification techniques in gastric most cancers: diagnostic relevance and prognostic worth. World J. Gastroenterol. 20, 5679–5684 (2014).
Nature CGARNJ Complete molecular characterization of gastric adenocarcinoma. 513 (7517), 202 (2014).
Cristescu, R. et al. Molecular evaluation of gastric most cancers identifies subtypes related to distinct scientific outcomes. Nat. Med. 21, 449–456 (2015).
Ricci, A. D., Rizzo, A. & Brandi, G. DNA injury response alterations in gastric most cancers: pulling down a brand new wall. Future Oncol. (London, England). 17(8), 865–868 (2021).
Rodriquenz, M. G. et al. MSI and EBV constructive gastric most cancers’s subgroups and their hyperlink with novel immunotherapy. J. Clin. Med. 9(5), 1427 (2020).
Yan, H. H. N. et al. A complete human gastric most cancers organoid biobank captures tumor subtype heterogeneity and permits therapeutic screening. Cell Stem Cell. 23, 882-897.e811 (2018).
Rizzo, A. et al. Peripheral neuropathy and headache in most cancers sufferers handled with immunotherapy and immuno-oncology mixtures: the MOUSEION-02 examine. Exp. Opin. Drug Metab. Toxicol. 17(12), 1455–1466 (2021).
Guven, D. C. et al. Immune checkpoint inhibitor-related listening to loss: a scientific evaluation and evaluation of particular person affected person knowledge. Help. Care Most cancers. 31(12), 624 (2023).
Rihawi, Okay. et al. Tumor-associated macrophages inflammatory microenvironment in gastric most cancers: novel translational implications. Int. J. Mol. Sci. 22(8), 3805 (2021).
Sahin, T. Okay., Rizzo, A., Aksoy, S. & Guven, D. C. Prognostic Significance of the Royal Marsden Hospital (RMH) Rating in Sufferers with Most cancers: A scientific evaluation and meta-analysis. Cancers. 16(10), 1835 (2024).
Tang, D., Kang, R., Berghe, T. V., Vandenabeele, P. & Kroemer, G. The molecular equipment of regulated cell demise. Cell Res. 29, 347–364 (2019).
Galluzzi, L. et al. Molecular mechanisms of cell demise: suggestions of the Nomenclature Committee on Cell Dying 2018. Cell Dying Differ. 25, 486–541 (2018).
Zou, Y. et al. Leveraging various cell-death patterns to foretell the prognosis and drug sensitivity of triple-negative breast most cancers sufferers after surgical procedure. Int. J. Surg. 107, 106936 (2022).
Su, Z., Yang, Z., Xu, Y., Chen, Y. & Yu, Q. Apoptosis, autophagy, necroptosis, and most cancers metastasis. Mol. Most cancers 14, 48 (2015).
Zhou, C. B. & Fang, J. Y. The function of pyroptosis in gastrointestinal most cancers and immune responses to intestinal microbial an infection. Biochim. Biophys. Acta Rev. Most cancers. 1872, 1–10 (2019).
Tu, R. H. et al. Neurotransmitter receptor HTR2B regulates lipid metabolism to inhibit ferroptosis in gastric most cancers. Most cancers Res. 83, 3868–3885 (2023).
Solar, L. et al. Lactylation of METTL16 promotes cuproptosis by way of m(6)A-modification on FDX1 mRNA in gastric most cancers. Nat. Commun. 14, 6523 (2023).
Shen, J. et al. The E3 ubiquitin ligase TRIM17 promotes gastric most cancers survival and development by way of controlling BAX stability and antagonizing apoptosis. Cell Dying Differ. 30, 2322–2335 (2023).
Strusi, G., Suelzu, C. M., Horwood, N., Münsterberg, A. E. & Bao, Y. Phenethyl isothiocyanate and dasatinib mixture synergistically reduces hepatocellular carcinoma development by way of cell cycle arrest and oxeiptosis. Entrance Pharmacol. 14, 1264032 (2023).
Maru, B. et al. PARP-1 improves leukemia outcomes by inducing parthanatos throughout chemotherapy. Cell Rep. Med. 4, 101191 (2023).
Ooi, C. H. et al. Oncogenic pathway mixtures predict scientific prognosis in gastric most cancers. PLoS Genet. 5, e1000676 (2009).
Pasini, F. S. et al. A gene expression profile associated to immune dampening within the tumor microenvironment is related to poor prognosis in gastric adenocarcinoma. J. Gastroenterol. 49, 1453–1466 (2014).
Jiang, H. et al. Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric most cancers utilizing single-cell RNA Sequencing. Clin. Transl. Med. 12, e730 (2022).
Hugo, W. et al. Genomic and transcriptomic options of response to anti-PD-1 remedy in metastatic melanoma. Cell 165, 35–44 (2016).
Jung, H. et al. DNA methylation loss promotes immune evasion of tumours with excessive mutation and replica quantity load. Nat. Commun. 10, 4278 (2019).
Balar, A. V. et al. Atezolizumab as first-line remedy in cisplatin-ineligible sufferers with domestically superior and metastatic urothelial carcinoma: a single-arm, multicentre, section 2 trial. Lancet. 389, 67–76 (2017).
Leek, J. T., Johnson, W. E., Parker, H. S., Jaffe, A. E. & Storey, J. D. The sva package deal for eradicating batch results and different undesirable variation in high-throughput experiments. Bioinformatics. 28, 882–883 (2012).
Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y. & Morishima, Okay. KEGG: new views on genomes, pathways, ailments and medicines. Nucleic Acids Res. 45, D353-d361 (2017).
Safran, M. et al. GeneCards Model 3: the human gene integrator. Database (Oxford) 2010, baq020 (2010).
Zhou, Y. et al. Implications of various cell demise patterns for prognosis and immunity in lung adenocarcinoma. NPJ Summary. Oncol. 7, 121 (2023).
Lu, X., Meng, J., Zhou, Y., Jiang, L. & Yan, F. MOVICS: an R package deal for multi-omics integration and visualization in most cancers subtyping. Bioinformatics. 36, 5539–5541 (2021).
Chalise, P. & Fridley, B. L. Integrative clustering of multi-level ‘omic knowledge based mostly on non-negative matrix factorization algorithm. PLoS One. 12, e0176278 (2017).
Barbie, D. A. et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 462, 108–112 (2009).
Sohn, B. H. et al. Scientific significance of 4 molecular subtypes of gastric most cancers recognized by the most cancers genome atlas venture. Clin. Most cancers Res. 23, 4441–4449 (2017).
Li, Y. et al. Proteomic characterization of gastric most cancers response to chemotherapy and focused remedy reveals new therapeutic methods. Nat. Commun. 13, 5723 (2022).
Lu, X. et al. Multi-omics consensus ensemble refines the classification of muscle-invasive bladder most cancers with stratified prognosis, tumour microenvironment and distinct sensitivity to frontline therapies. Clin. Transl. Med. 11, e601 (2021).
Audia, J. E. & Campbell, R. M. Histone modifications and most cancers. Chilly Spring Harb. Perspect. Biol. 8, a019521 (2016).
Zeng, D. et al. IOBR: Multi-omics immuno-oncology organic analysis to decode tumor microenvironment and signatures. Entrance. Immunol. 12, 687975 (2021).
Xu, L. et al. TIP: An internet server for resolving tumor immunophenotype profiling. Most cancers Res. 78, 6575–6580 (2018).
Subramanian, A. et al. Gene set enrichment evaluation: a knowledge-based method for deciphering genome-wide expression profiles. Proc. Natl. Acad. Sci. U S A. 102, 15545–15550 (2005).
Stuart, T. et al. Complete integration of single-cell knowledge. Cell. 177, 1888-1902.e1821 (2019).
Jin, S. et al. Inference and evaluation of cell-cell communication utilizing Cell Chat. Nat. Commun. 12, 1088 (2021).
Uhlén, M. et al. Proteomics. Tissue-based map of the human proteome. Science. 347, 1260419 (2015).
Wang, S. F. et al. Development differentiation issue 15 induces cisplatin resistance via upregulation of xCT expression and glutathione synthesis in gastric most cancers. Most cancers Sci. 114, 3301–3317 (2023).
Zhang, C. et al. The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to advertise most cancers growth. J. Immunother. Most cancers. 11, e006230 (2023).
Lin, J. X. et al. Neoadjuvant camrelizumab and apatinib mixed with chemotherapy versus chemotherapy alone for domestically superior gastric most cancers: a multicenter randomized section 2 trial. Nat. Commun. 15, 41 (2024).
Lei, Z. N. et al. Signaling pathways and therapeutic interventions in gastric most cancers. Sign. Transduct. Goal Ther. 7, 358 (2022).
Liu, J. Z. et al. BDH2 triggers ROS-induced cell demise and autophagy by selling Nrf2 ubiquitination in gastric most cancers. J. Exp. Clin. Most cancers Res. 39, 123 (2020).
Rizzo, A. et al. Third- and later-line remedy in superior or metastatic gastric most cancers: a scientific evaluation and meta-analysis. Future Oncol. 16, 4409–4418 (2020).
Vitale, E., Rizzo, A., Santa, Okay. & Jirillo, E. Associations between “Most cancers Danger”, “Irritation” and “Metabolic Syndrome”: A Scoping Overview. Biology (Basel). 13(5), 352 (2024).
Viscardi, G. et al. Comparative evaluation of early mortality danger upon immune checkpoint inhibitors alone or together with different brokers throughout strong malignancies: a scientific evaluation and meta-analysis. Eur. J. Most cancers. 177, 175–185 (2022).
Meng, Q. et al. DNA methylation regulator-mediated modification patterns and tumor microenvironment characterization in gastric most cancers. Mol. Ther. Nucleic Acids. 24, 695–710 (2021).
Peng, Y., Shi, R., Yang, S. & Zhu, J. Cuproptosis-related gene DLAT is a biomarker of the prognosis and immune microenvironment of gastric most cancers and impacts the invasion and migration of cells. Most cancers Med. 13, e70012 (2024).
Wang, S. et al. PTBP1 knockdown impairs autophagy flux and inhibits gastric most cancers development via TXNIP-mediated oxidative stress. Cell Mol. Biol. Lett. 29, 110 (2024).
Cheng, X. et al. Atlas of metastatic gastric most cancers hyperlinks ferroptosis to illness development and immunotherapy response. Gastroenterology. https://doi.org/10.1053/j.gastro.2024.07.038 (2024).
Guo, D. et al. Celastrol induces necroptosis and ameliorates irritation by way of concentrating on biglycan in human gastric carcinoma. Int. J. Mol. Sci. 20(22), 5716 (2019).
Wang, W. et al. CXCR4 induces cell autophagy and maintains EBV latent an infection in EBVaGC. Theranostics. 10, 11549–11561 (2020).
Chen, Q., Xu, X. Y., Hou, X. X. & Chen, S. C. The upregulation of proteins mild chain 3 and autophagy-related 5 and the occurence of intestinal-type gastric most cancers. J. Physiol. Pharmacol. 72(6), 8 (2021).
Minikes, A. M. et al. E-cadherin is a biomarker for ferroptosis sensitivity in diffuse gastric most cancers. Oncogene. 42, 848–857 (2023).
Yang, J. et al. FABP4 in macrophages facilitates obesity-associated pancreatic most cancers development by way of the NLRP3/IL-1β axis. Most cancers Lett. 575, 216403 (2023).
Mónaco, A., Chilibroste, S., Yim, L., Chabalgoity, J. A. & Moreno, M. Inflammasome activation, NLRP3 engagement and macrophage recruitment to tumor microenvironment are all required for Salmonella antitumor impact. Most cancers Immunol. Immunother. 71, 2141–2150 (2022).
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L. & Kroemer, G. Immunogenic cell demise in most cancers and infectious illness. Nat. Rev. Immunol. 17, 97–111 (2017).
Tang, D., Chen, X., Kang, R. & Kroemer, G. Ferroptosis: molecular mechanisms and well being implications. Cell Res. 31, 107–125 (2021).
Jung, Y. J. et al. Impact of IL-10-producing B cells in peripheral blood and tumor tissue on gastric most cancers. Cell Commun. Sign. 21, 320 (2023).
Yousefi, B. et al. Epigenetic adjustments in gastric most cancers induction by Helicobacter pylori. J Cell Physiol. 234, 21770–21784 (2019).
Farasati Far, B. et al. The function of microRNA-21 (miR-21) in pathogenesis, analysis, and prognosis of gastrointestinal cancers: A evaluation. Life Sci. 316, 121340 (2023).
Perillo, B. et al. ROS in most cancers remedy: the intense aspect of the moon. Exp. Mol. Med. 52, 192–203 (2020).
Timmerman, D. M., Remmers, T. L., Hillenius, S. & Looijenga, L. H. J. Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells-Relevance for Understanding (Germ Cell) Tumorigenesis. Int. Mol. Sci. 22(10), 5377 (2021).
Nam, D., Chapiro, J., Paradis, V., Seraphin, T. P. & Kather, J. N. Synthetic intelligence in liver ailments: Enhancing diagnostics, prognostics and response prediction. JHEP Rep. 4, 100443 (2022).
Hu, J. et al. A novel pyroptosis gene expression-based danger rating for survival in gastric most cancers. Entrance Endocrinol. (Lausanne). 14, 1120216 (2023).
Shen, Y. et al. Cross-talk between cuproptosis and ferroptosis regulators defines the tumor microenvironment for the prediction of prognosis and therapies in lung adenocarcinoma. Entrance Immunol. 13, 1029092 (2022).
Huang, X. Z. et al. Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution throughout gastric most cancers peritoneal metastasis. Nat. Commun. 14, 822 (2023).
Zulibiya, A. et al. Single-cell RNA sequencing reveals potential for endothelial-to-mesenchymal transition in tetralogy of fallot. Congenit. Coronary heart Dis. 18, 611–625 (2023).
Qu, X. et al. Lack of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric most cancers. Drug Resist. Updat. 68, 100936 (2023).
Li, X. et al. Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup related to poor scientific outcomes in sufferers with gastric most cancers. Theranostics. 12, 620–638 (2022).
Maeda, M. et al. Most cancers cell area of interest elements secreted from cancer-associated fibroblast by lack of H3K27me3. Intestine. 69, 243–251 (2020).
Foote, H.-P. et al. Utilizing pharmacokinetic modeling and digital well being file knowledge to foretell scientific and security outcomes after methylprednisolone publicity throughout cardiopulmonary bypass in neonates. Congenit. Coronary heart Dis. 18, 295–313 (2023).
Hui, Y., Tu, C., Liu, D., Zhang, H. & Gong, X. Danger elements for gastric most cancers: A complete evaluation of observational research. Entrance. Public Well being. 10, 892468 (2022).
Mohseni, S. et al. Impact of nutritional vitamins C and E on most cancers survival; a scientific evaluation. Daru. 30, 427–441 (2022).
Usui, Y. et al. Helicobacter pylori, homologous-recombination genes, and gastric most cancers. N. Engl. J. Med. 388, 1181–1190 (2023).